M. Andrew (1,2,3), M. Hebert (4,5), P. Vicini (1,6) Physiologically Based Pharmacokinetic (PBPK) Modeling of Midazolam Disposition in Pregnant and Postpartum Women
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W. Krzyzanski An Interpretation of Transit Compartment Pharmacodynamic Models As Lifespan Based Indirect Response Models.
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K. Thelen (1), K. Coboeken (2), S. Willmann (2), J.B. Dressman (1), J. Lippert (2) A novel physiological model to simulate gastrointestinal fluid dynamics, transit of luminal contents, absorption, and pre-systemic metabolism of orally administered drugs in humans
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Linus Görlitz, Michael Block, Jörg Lippert Identifying cancer drug MoAs and cell-line properties using signaling cascade models and Bayesian analysis: From throw-away experiments to persistent information
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K. Claaßen (1), S. Willmann (2), K. Thelen (3), K. Coboeken (2), K. Allegaert (4), J. Lippert (2) Physiology-based Simulations of Amikacin Pharmacokinetics in Preterm Neonates
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Michael Block, Linus Görlitz, Clara Happ, Rolf Burghaus, Jörg Lippert Separating individual physiological variability from drug related properties using PBPK Modeling with PK-Sim® and MoBi® – Theophylline
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Thomas Eissing, Michael Block, Katrin Coboeken, Thomas Gaub, Lars Kuepfer, Michaela Meyer, Michael Sevestre, Juri Solodenko, Joerg Lippert Clinical trial simulation with multiscale models: Integrating whole-body physiology, disease biology, and molecular reaction networks
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Christoph Niederalt(1), Lars Kuepfer(1), Thomas Wendl(1), Stefan Willmann(1), Jörg Lippert(1), Victoria Flores(2) & Piet van der Graaf(2) Mechanistic analysis of fusion proteins: PBPK applied in an Albuferon case study
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M. Meyer, L. Kuepfer, D. Chandra Prakash, S. Schneckener, B. Ludewig, J. Lippert Using relative gene expression measurements for PBPK modeling of pravastatin
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M. Meyer (1), S. Willmann (1), C. Becker (2), R. Burghaus (2), W. Mueck (2), J. Lippert (1) Influence of CYP1A1 induction by cigarette smoke on pharmacokinetics of erlotinib: a computer-based evaluation of smoke-induced CYP1A1 activity in different tissues
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J. Lippert(1), K. Boland(2), S. Willmann(1), E. Hizaler Hoffmann(1), A. Sensse(1), M. Sevestre(1), R. Pyke(3), A. Staab(2) Simulation of the pharmacokinetics of flibanserin under itraconazole co-mediaction with an integrated physiologically-based pharmacokinetic model
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M. Kallenbach (1), J. Hövener (2), G. Kersting (1,2), S. Willmann (3), J. Lippert (3), J. Boos (1), G. Hempel (1,2) Evaluation of a Physiologically-Based Pharmacokinetic (PBPK) Model for the Application of Low Dose Etoposide in Children
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Parra-Guillen ZP(1), Hernandez-Alcoceba R(2), Gonzalez-Aseguinolaza G(2), Berraondo P(2), Troconiz IF(1) Nonlinear Pharmacokinetic Model For Interleukin-12 Gene Therapy
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C. Gérard (1,2), N. Bleyzac (3,4), P. Girard (1,2), G. Freyer (1,2), Y. Bertrand (3), M. Tod (1,2,5). Influence of cyclosporin dosing schedule on receptor occupancy in bone marrow transplantation: analysis with a PBPK-PD model
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Sabine Pilari and Wilhelm Huisinga Lumping of Physiologically Based Pharmacokinetic Models and a Mechanistic Derivation of Classical Compartmental Models
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